Evolution, structure, rapid rotation Georges Meynet Astronomical Observatory of the Geneva University In a first part, we shall review the effects of rotation on the structure and the evolution of massive stars. Emphasis will be given on the predictions of rotating stellar models which might be constrained by interferometric observations as, for instance, the shape of fast rotating stars, the variation of the effective temperature as a function of the colatitude and the anisotropies of the mass loss. In a second part, we shall show why these observational constraints are of key importance to make progresses on topical astrophysical questions as the nature of the progenitors of Be stars and of Gamma Ray Bursts, the evolution of the first massive star generations in the Universe and the impact of fast rotating metal poor massive stars on the photometric and chemical evolution of various stellar systems.